1. ANTICONVULSANT STUDIES OF THREE SYNTHESIZED DICHLOROSUBSTITUTED PHENYL PROPANAMIDES AND THEIR ACTION ON VOLTAGE-GATED SODIUM CHANNELS (Nav1.6)
Abstract
The field of antiepileptic drug development has become dynamic, affording many promising research opportunities. Continued efforts are being made in the development of antiepileptic drugs employing a range of strategies, including modification of the structures of existing drug...
2. SYNTHESIS AND ANTICONVULSANT SCREENING OF THREE ISOMERIC 3-(DIMETHYLPHENYL)AMINOPROPANAMIDES
ABSTRACT
Tremendous effort was made in this work to synthesize the three isomeric 3- (dimethylphenyl)aminopropanamides through the Michael nucleophilic substitution reaction. However, some of the results obtained after spectroscopic analysis did not satisfactorily conform to the structu...
3. SYNTHESIS AND ANTICONVULSANT STUDIES OF 3-ANILINOPROPANAMIDES AND THEIR N-BENZYL DERIVATIVES
Abstract
The 3-ANPs (A01-A10) were prepared through acid catalysed Michael addition while the N-benzyl derivatives (A11-A15) were obtained through an uncatalysed amine exchange reaction with benzylamine. The structures of these compounds were established using various spectroscopic tech...
