1. A STUDY OF SALIVA AND CHEEK CELLS DNA EXTRACTION WITH THE USE OF HOUSEHOLD CHEMICALS
1.1 BACKGROUND OF THE STUDY
Genomic DNA is an essential kind of nucleic acid that may be extracted for use in scientific study and forensic analysis (Dumache et al, 2016). After the DNA has been extract...
2. COMPARISON OF THE EFFECTS OF CIMETIDINE AND DIAZEPAM ON THE PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at...
3. COMPARATIVE RELATIVE BIOAVAILABILITY STUDIES OF SIX BRANDS OF OFLOXACIN MARKETED
ABSTRACT
This study was aimed at assessing the comparative bioavailability of six brands of ofloxacin marketed in Zaria. Comparative bioavailability studies of six brands of ofloxacin marketed in Zaria was successfully conducted. Quality assessment was conducted on the randomly selected...
4. COMPARISON OF THE EFFECTS OF CIMETIDINE AND TRAMADOL ON THE DISPOSITION OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
The influence of cimetidine (400mg) and Tramadol (100mg) on the disposition of oral single dose (1g) Paracetamol was studied and compared in 8 healthy human volunteers under two protocols; concomitant and delayed paracetamol administration. Subjects received one treatment at ea...
5. COMPARATIVE BIOEQUIVALENCE STUDIES OF SOME SELECTED BRANDS OF CIPROFLOXACIN TABLETS MARKETED IN NIGERIA
ABSTRACT
Comparative bioequivalence studies of six selected brands of ciprofloxacin tablets was successfully conducted. In-vitro quality control studies were carried out on six randomly selected brands of ciprofloxacin to establish identity, weight uniformity, friability, crushing stren...
6. COMPARISON OF THE EFFECTS OF CIMETIDINE AND METHYLDOPA ON THE PHARMACOKINETICS OF PARACETAMOL IN HUMAN
ABSTRACT
Comparison of the effects of cimetidine and methyldopa were studied in 5 phases: via phase I, ingestion of paracetamol 1g alone, phase II, administration of paracetamol 1g and cimetidine 400mg concurrently, phase III administration of cimetidine 400mg followed by paracetamol 1g...
7. COMPARATIVE BIOAVAILABILITY STUDIES OF PARACETAMOL BRANDS IN HUMANS
ABSTRACT
The comparative bioavailabilities (bioequivalence) of five generic brands of paracetamol were compared in six (6) healthy male volunteers. The aim was to study whether the generic brands are bioequivalent to the standard brand. The study was carried out following oral administr...
8. COMPARISON OF THE EFFECT OF A SINGLE ORAL DOSE OF CIMETIDINE AND PROPANTHELINE ON THE PHARMACOKINETIC OF PARACETAMOL IN HUMAN
ABSTRACT
Comparison of the effects of a single oral dose of cimetidine and propantheline on the pharmacokinetics of paracetamol were studied with paracetamol (1g) administered alone, concurrently with cimetidine (400mg), delay (1 hour) with cimetidine (400mg), concurrently with paraceta...
9. EFFECT OF CAFFEINE ON PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS: A CASE STUDY OF PANADOL EXTRA®
ABSTRACT
Acetaminophen or paracetamol is an analgesic and anti-pyretic agent widely used for treatment of headaches, minor pains and in combination with other medications like cold remedies and opoid analgesics. Individuals with headaches and minor pains tend to use paracetamol with caf...
10. EFFECT OF RANITIDINE ON PHARMACOKINETIC PARAMETERS OF METRONIDAZOLE IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
Pharmacokinetics is the study of the time course of drug movement in the body during absorption, distribution, metabolism and elimination.Drug interactions are pharmacodynamic, pharmacokinetic, or clinical responses to the administration of a drugcombination that differs from t...
11. EFFECTS OF ENVIRONMENTAL EXPOSURE ON THE PHARMACOKINETICS OF CIPROFLOXACIN TABLET IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
Ciprofloxacin is a flouroquinololone antibiotic that is commonly prescribed empirically in Nigeria due to its broad spectrum of activity. However, the drug product is illegally handled by drug hawkers that allow the drug to be exposed to some environmental forces which may affe...
